In September 1971, Meisner, along with Henley, Frey and Leadon, formed the Eagles, signing with David Geffen's new label, Asylum Records, and they released their eponymous debut album in 1972. While he usually manned the bass and handled backing vocals for the Eagles, he also played guitar on Desperado, On the Border, and Hotel California. During his six years with the band, he wrote and/or co-wrote songs on each of the group's first five albums—most notably "Take It to the Limit" on One of These Nights—and was featured as lead vocalist on several other songs.On his abrupt resignation from the band, Meisner has said, "When I quit, it was like Timothy Schmit joined the group, and it was like Timothy was the guy now, and I can't blame them for that. All that stuff and all the arguing amongst the Eagles is over now. Well at least for me."

Meisner went on to release solo albums in 1978 Randy Meisner and 1980 (One More Song). In 1981, he toured with his band Randy Meisner & the Silverados, and in 1982 he released an album on CBS called (Randy Meisner), recorded with members of Heart. He also resumed his session-playing, supporting James Taylor, Joe Walsh, Dan Fogelberg, Bob Welch, Richie Furay, Richard Marx, Peter Lewis, Danny O'Keefe, Mac Gayden & Electric Range, as well as being part of the one-hit band Black Tie (a cover of Buddy Holly's "Learning the Game") - featuring Meisner alongside Jimmy Griffin (of Bread) and Billy Swan. When Griffin departed and was replaced by Charlie Rich, Jr., the band was renamed "Meisner, Swan & Rich."

This solo song hit #19 back in 1981