"Up on Cripple Creek" is the fifth song on The Band's eponymous second album, The Band. It was released as a (edited) single on Capitol 2635 in November 1969 and reached #25 on the Billboard Hot 100.

A live performance of "Up on Cripple Creek" appears in The Band's live concert film The Last Waltz, as well as on the accompanying soundtrack album. In addition, a live version of the song appears on Before the Flood; a live album of The Band's various concerts and shows with Bob Dylan while touring together in 1974.

"Up on Cripple Creek" is notable as it is one of the first accounts of a Hohner Clavinet being played with a wah-wah pedal. The riff can be heard after the chorus of the song. The Clavinet, especially in tandem with a wah pedal was a sound that became famous in the early to mid '70s especially in funk music, and continues to be popular to this day.

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